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Anti-Factor IXa, X Antibody, Non-Fucosylated (BioBet-1792ZP) (CAT#: BioBet-1792ZP) Datasheet

Target
Factor IXa, X
Isotype
IgG1
Description
Anti-Factor IXa, X Antibody, Non-Fucosylated (BioBet-1792ZP) is a humanized monoclonal IgG1 antibody against Factor IXa, X. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hemophilia A (congenital Factor VIII deficiency) with Factor VIII inhibitors
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Factor IXa, X antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Factor IX
Full Name
Factor IX (or Christmas factor)
Background
Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia.
Alternative Names
F9, F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Blood coagulation factor IX, Christmas Factor
Gene ID
Human: 2158; Mouse: 14071
UniProt ID
Human: P00740; Mouse: P16294
Genecards
F9
Involvement in Disease
Diseases associated with F9 include Hemophilia B and Thrombophilia, X-Linked, Due To Factor Ix Defect. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Gamma carboxylation, hypusine formation and arylsulfatase activation.
Function
Factor IX is a vitamin K-dependent plasma protein that converts factor X into its active form in the presence of Ca(2+) ions, phospholipids and factor VIIIa, thereby participating in the internal pathway of blood coagulation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-1792ZP
Host
Humanized
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Hemophilia A (congenital Factor VIII deficiency) with Factor VIII inhibitors

Hemophilia A (congenital Factor VIII deficiency) with Factor VIII inhibitors

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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