Description
Anti-ETS Translocation Variant 1 Antibody, Non-Fucosylated (BioBet-846ZP) is a mouse monoclonal IgG antibody against ETS translocation variant 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Gastrointestinal Stromal Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ETS translocation variant 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ETV1
Full Name
ets variant 1
Background
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5-CGGA-3. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Alternative Names
ETV1; ets variant 1; ER81; ETS translocation variant 1; ets variant gene 1; ets-related protein 81
Gene ID
2115
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with ETV1 include Ewing Sarcoma and Gastrointestinal Stromal Tumor.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and Development_TGF-beta receptor signaling.
Function
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Post-translational modifications
Sumoylated. Phosphorylated at Ser-191 and Ser-216 by RPS6KA1 and RPS6KA5; phosphorylation activates transcriptional activity.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-846ZP
Description
The monoclonal antibody that bind to the ETV1 protein can be used as a diagnostic, prognostic and therapeutic target for gastrointestinal stromal tumors.
Antibody Indication
Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors
