Anti-EPHB4 Antibody, Non-Fucosylated (BioBet-833ZP) (CAT#: BioBet-833ZP) Datasheet

EPHB4

EPH receptor B4

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

EPHB4; EPH receptor B4; HTK; MYK1; TYRO11; ephrin type-B receptor 4; ephrin receptor EphB4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; hepatoma transmembrane kinase; tyrosine-protein kinase TYRO11; tyrosine-protein kinase receptor HTK

Plasma membrane

Diseases associated with EPHB4 include Capillary Malformation-Arteriovenous Malformation 2 and Lymphatic Malformation 7.

Its related pathways are Activation of cAMP-Dependent PKA and Actin Nucleation by ARP-WASP Complex.

Receptor tyrosine kinases, which bind to transmembrane ephrin-B family ligands residing on neighboring cells, resulting in contact-dependent bidirectional signaling to neighboring cells. The signal pathway downstream of the receptor is called the forward signal, and the signal pathway downstream of the ephrin ligand is called the reverse signal. Together with its cognate ligand/functional ligand EFNB2, it participates in regulating cell adhesion and migration, and plays a central role in cardiac morphogenesis, angiogenesis, vascular remodeling and vascular permeability. The ephb4-mediated positive signal controls the rejection and separation of efnb2 expressing cells.

Phosphorylated; autophosphorylation is stimulated by EFNB2.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-833ZP

Human

Human

The anti-ephb4 antibody can be used in treatment of oncology and vasculogenesis-related disease.

Cancer

Cancer