Anti-EphB2 Antibody, Non-Fucosylated (B11) (CAT#: BioBet-805ZP) Datasheet

EFNB2

ephrin-B2

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

EFNB2; ephrin-B2; HTKL; EPLG5; Htk-L; LERK5; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5

Plasma membrane

Diseases associated with EFNB2 include Nodular Regenerative Hyperplasia and Arteriovenous Malformation.

Its related pathways are EphB-EphrinB Signaling and Axon guidance.

As the cell surface transmembrane ligand of the Eph receptor, the receptor tyrosine kinase family is key to the development of neurons, blood vessels and epithelium during migration, rejection and adhesion. The disorderly binding of Eph receptors that live on neighboring cells causes contact-dependent bidirectional signals to enter neighboring cells. The signal pathway downstream of the receptor is called the forward signal, and the signal pathway downstream of the ephrin ligand is called the reverse signal. Binding receptor tyrosine kinases include EPHA4, EPHA3 and EPHB4. Together with EPHB4, it plays a central role in cardiac morphogenesis and angiogenesis by regulating cell adhesion and cell migration. The ephb4-mediated positive signal controls the rejection and separation of efnb2 expressing cells. It may act in the direction of restricting longitudinally projecting axons.

Cancer antibody; Cell Biology and Cellular Response antibody; Neuroscience antibody

Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

B11

Human

Human

It is an antibody capable of binding to ephrin B2 and inhibiting the angiogenetic activity of ephrin B2 and the proliferation activity of a mammary gland tissue.

Cancer

Cancer