Anti-EPHA7 Antibody, Non-Fucosylated (CAT#: BioBet-829ZP) Datasheet

EPHA7

EPH receptor A7

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants.

EPHA7; EPH receptor A7; EHK3; EK11; EHK-3; HEK11; ephrin type-A receptor 7; EPH-like kinase 11; EPH homology kinase 3; Eph homology kinase-3; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3

Plasma membrane

Diseases associated with EPHA7 include Brachydactyly-Syndactyly Syndrome and Gallbladder Adenocarcinoma.

Its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA.

Receptor tyrosine kinases can freely bind gpi-anchored ephrin-a ligand that resides in neighboring cells, resulting in contact-dependent bidirectional signaling to neighboring cells. The signal pathway downstream of the receptor is called the forward signal, and the signal pathway downstream of the ephrin ligand is called the reverse signal. Among gpi-fixed ephrin-A ligands, EFNA5 is the homologous/functional ligand of EPHA7, and their interaction regulates brain development and regulates cell adhesion and rejection. It has a repulsive effect on axons. For example, it participates in the guidance of corticothalamic axons and the correct topographical mapping of retinal axons to colliculus. It is also possible that caspase (CASP3)-dependent pro-apoptotic activity regulates brain development. The forward signal may cause the activation of MAP2K1, MAP2K2, MAPK1 and MAPK3 in the ERK signaling pathway, and these components are phosphorylated after EPHA7 is activated.

Phosphorylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-829ZP

Mouse

Human

This is an antibody againsts EPHA7, it can be used to treat and diagnose cancer.

Cancer

Cancer