Anti-EPHA4 Antibody, Non-Fucosylated (CAT#: BioBet-827ZP) Datasheet

EPHA4

EPH receptor A4

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8

Plasma membrane, Endosome

Diseases associated with EPHA4 include Amyotrophic Lateral Sclerosis 1 and Duane Retraction Syndrome.

Its related pathways are Gene regulatory network modelling somitogenesis and Guidance Cues and Growth Cone Motility.

Receptor tyrosine kinases bind to membrane-bound ephrin family ligands residing in neighboring cells, resulting in contact-dependent bidirectional signaling to neighboring cells. The signal pathway downstream of the receptor is called the forward signal, and the signal pathway downstream of the ephrin ligand is called the reverse signal. It has unique properties in the Eph receptor, which can bind to and be activated physiologically by gpi-fixed ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Once the ephrin ligand is activated, it regulates cell morphology and integrin-dependent cell adhesion by regulating the activities of Rac, Rap and Rho GTPases. It plays an important role in the development of the nervous system, controlling the different steps of axons, including the establishment of corticospinal projection. It can also control the separation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axon guidance, it also plays a role in synaptic plasticity. The tyr15 site of CDK5 is phosphorylated by EFNA1 to phosphorylate NGEF, which regulates RHOA and dendritic spines morphology. In the nervous system, it also plays a role in repairing after injury, preventing axon regeneration and angiogenesis, and plays a role in the formation of blood vessels in the central nervous system. In addition, its chaotic nature allows it to participate in a variety of cell-cell signal regulation, such as the development of thymic epithelium. During the development of the Corti organ of the cochlea, the separation of the regulatory column cells by forming a triple complex with ADAM10 and CADH1 promotes the cleavage of CADH1 and the destruction of adhesion connections by ADAM10 (through similarity).

1.Glycosylation at Asn235, Asn340, Asn408, and Asn545 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys735

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

EA44

Mouse

Human

The antibody specific for EphA4 inhibit a cancer cell phenotype, preferentially bind epitopes on EphA4 that are selectively exposed or increased on cancer cells but not non-cancer cells and/or bind EphA4. The antibody are useful for hyperproliferative cell disease, particularly cancer therapy.

Cancer

Cancer