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Anti-Endosialin Antibody, Non-Fucosylated (BioBet-651ZP) (CAT#: BioBet-651ZP) Datasheet

Target
Endosialin
Isotype
IgG
Description
Anti-Endosialin Antibody, Non-Fucosylated (BioBet-651ZP) is a humanized monoclonal IgG antibody against Endosialin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Endosialin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD248
Full Name
CD248 molecule, endosialin
Alternative Names
CD248; CD248 molecule, endosialin; TEM1; CD164L1; endosialin; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; tumor endothelial marker 1
Gene ID
57124
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with CD248 include Vascular Cancer and Adult Fibrosarcoma.
Function
May play a role in tumor angiogenesis.
Post-translational modifications
1.O-glycosylated with sialylated oligosaccharides 2.Modification sites at PhosphoSitePlus 3.May be N-glycosylated 4.Glycosylation at Thr60, Thr401, Thr428, Thr448, Thr456, Thr459, Thr472, Thr519, Thr541, Thr543, Thr544, Thr545, Thr587, Thr593, Thr594, Thr595, Ser598, Ser601, Thr612, Thr619, Ser623, Ser625, Thr627, Thr630, Ser631, Thr636, and Ser640
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-651ZP
Host
Humanized
Species Reactivity
Human
Description
This is an antibody binds specifically to an endosialin tumor endothelial marker 1 (TEM1), Tumor endothelial marker 1 (TEM1 or endosialin, CD248) has been identified, which is highly expressed on the tumor vessels but not on the vessels in the normal, healthy tissue.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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