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Anti-EMR1 Antibody, Non-Fucosylated (19-1E7) (CAT#: BioBet-528ZP) Datasheet

Target
EMR1
Isotype
IgG1k
Description
Anti-EMR1 Antibody, Non-Fucosylated (BioBet-528ZP) is a humanized monoclonal IgG1k antibody against EMR1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
EMR1-related diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced EMR1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ADGRE1
Full Name
egf-like module containing, mucin-like, hormone receptor-like 1
Background
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
EMR1; egf-like module containing, mucin-like, hormone receptor-like 1; TM7LN3; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; EGF-like module receptor 1; egf-like module containing, mucin-like, hormone receptor-like sequence 1
Gene ID
2015
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ADGRE1 include Vibratory Urticaria.
Related Pathways
Its related pathways are Signaling by GPCR and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Field of research
Mouse Inflammatory Cell Marker antibody; Macrophage Marker antibody
Post-translational modifications
1.Glycosylation at Asn232, Asn94, Asn99, Asn167, Asn258, Asn127, Asn189, Asn194, Asn312, Asn366, Asn375, and Asn448 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1k
Antibody Clone
19-1E7
Host
Humanized
Species Reactivity
Human
Description
antibody that bind to EMR1 are known. However, there is a need for the development of therapeutic antibody that selectively target EMR-1 and deplete eosinophils.
Antibody Indication
EMR1-related diseases

EMR1-related diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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