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Anti-EDAR Antibody, Non-Fucosylated (BioBet-802ZP) (CAT#: BioBet-802ZP) Datasheet

Target
EDAR
Isotype
IgG
Description
ADCC-Enhanced anti-EDAR (mAbEDAR3) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
X-linked hypohidrotic ectodermal dysplasia; Tooth agenesis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced EDAR antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
EDAR
Full Name
ectodysplasin A receptor
Background
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
Alternative Names
EDAR; ectodysplasin A receptor; DL; ED3; ED5; ED1R; EDA3; HRM1; EDA1R; ECTD10A; ECTD10B; EDA-A1R; tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; downless homolog; ectodysplasin-A receptor; downless, mouse, homolog of; ectodermal dysplasia receptor; anhidrotic ectodysplasin receptor 1; ectodysplasin 1, anhidrotic receptor
Gene ID
10913
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with EDAR include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Ectodermal Dysplasia 10B, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and PEDF Induced Signaling.
Function
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Post-translational modifications
1.Glycosylation at Asn38 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
mAbEDAR3
Host
Mouse
Species Reactivity
Human
Description
The anti-EDAR monoclonal antibody can be used in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis.
Antibody Indication
X-linked hypohidrotic ectodermal dysplasia; Tooth agenesis

X-linked hypohidrotic ectodermal dysplasia; Tooth agenesis

Related Products

Anti-EDAR Antibody, Non-Fucosylated (BioBet-801ZP) (CAT#: BioBet-801ZP)
Anti-EDAR Antibody, Non-Fucosylated (BioBet-803ZP) (CAT#: BioBet-803ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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