Description
ADCC-Enhanced anti-EDA1 (EctoD1) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Skin Disorders; Disorders related to excessive action of EDA1
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced EDA1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Alternative Names
EDA; ectodysplasin A; ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; STHAGX1; ectodysplasin-A; oligodontia 1; X-linked anhidroitic ectodermal dysplasia protein
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with EDA include Ectodermal Dysplasia 1, Hypohidrotic, X-Linked and Tooth Agenesis, Selective, X-Linked, 1.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and PEDF Induced Signaling.
Function
Cytokines are involved in epithelial-mesenchymal signal transduction during the morphogenesis of ectodermal organs. Acts as a ligand to activate the death zone containing receptors EDAR and EDA2R. It may also play a role in cell adhesion (through similarity). [Heterotype 1]: Only binds to the receptor EDAR, and Heterotype 3 only binds to the receptor EDA2R. [Heterotype 3]: Only binds to the receptor EDA2R.
Post-translational modifications
N-glycosylated. Processing by furin produces a secreted form.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The anti-EDA1 monoclonal antibody may be used in the treatment of disorders relating to excessive action of EDA1 such as hirsutism, ectopic teeth, hyperhidrosis, breast cancer, dermal eccrine cylindroma or skin disorders such as sebaceous gland hyperplasia, comedones, milia, acne, seborrhea, rosacea, steatoma, and furuncles. The anti-EDA1 antibody are also useful in immunoassays such as sandwich ELISA.
Antibody Indication
Skin Disorders; Disorders related to excessive action of EDA1
