Anti-EAG1 ion channel Antibody, Non-Fucosylated (BioBet-1144ZP) (CAT#: BioBet-1144ZP) Datasheet

KCNH1

potassium channel, voltage gated eag related subfamily H, member 1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

KCNH1; potassium channel, voltage gated eag related subfamily H, member 1; EAG; EAG1; h-eag; Kv10.1; potassium voltage-gated channel subfamily H member 1; hEAG1; EAG channel 1; ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; voltage-gated potassium channel subunit Kv10.1; potassium voltage-gated channel, subfamily H (eag-related), member 1

Plasma membrane, Nucleus, Endosome

Diseases associated with KCNH1 include Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome 1.

Its related pathways are Potassium Channels and Transmission across Chemical Synapses.

The subunit channel properties of alpha voltage-gated delayed rectifier potassium channels are modulated by subunit components to regulate IK (NI) current in myoblasts. Participate in the regulation of cell proliferation and differentiation, especially the adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs).

1.Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn415 and Asn433

Protein Based Therapies
Monoclonal antibody (mAb)

IgGI

BioBet-1144ZP

Human

Human

The antibody which specifically binds to/interacts with EAG1 ion channel can be used for the treatment of a hyperproliferative disease, inflammatory disease, psoriasis, or a neurodegenerative disease.

Inflammatory Diseases

Inflammatory Diseases