Description
Anti-EAG1 ion channel Antibody, Non-Fucosylated (BioBet-1144ZP) is a human monoclonal IgGI antibody against EAG1 ion channel. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced EAG1 ion channel antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
KCNH1
Full Name
potassium channel, voltage gated eag related subfamily H, member 1
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
Alternative Names
KCNH1; potassium channel, voltage gated eag related subfamily H, member 1; EAG; EAG1; h-eag; Kv10.1; potassium voltage-gated channel subfamily H member 1; hEAG1; EAG channel 1; ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; voltage-gated potassium channel subunit Kv10.1; potassium voltage-gated channel, subfamily H (eag-related), member 1
Gene ID
3756
Cellular Localization
Plasma membrane, Nucleus, Endosome
Involvement in Disease
Diseases associated with KCNH1 include Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome 1.
Related Pathways
Its related pathways are Potassium Channels and Transmission across Chemical Synapses.
Function
The subunit channel properties of alpha voltage-gated delayed rectifier potassium channels are modulated by subunit components to regulate IK (NI) current in myoblasts. Participate in the regulation of cell proliferation and differentiation, especially the adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs).
Post-translational modifications
1.Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn415 and Asn433
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgGI
Antibody Clone
BioBet-1144ZP
Description
The antibody which specifically binds to/interacts with EAG1 ion channel can be used for the treatment of a hyperproliferative disease, inflammatory disease, psoriasis, or a neurodegenerative disease.
Antibody Indication
Inflammatory Diseases
