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Anti-E. coli Stx1B Antibody, Highly Galactosylated (BioBet-GA-190ZP) (CAT#: BioBet-GA-190ZP) Datasheet

Target
E. coli Stx1B
Isotype
IgG1, κ
Description
Anti-E. coli Stx1B Antibody, Highly Galactosylated (BioBet-GA-190ZP) is a chimeric IgG1, κ antibody against E. coli Stx1B which contains with a high level of galactosylation.
Antibody Indication
STEC (Shiga-like toxin-producing Escherichia coli or E. coli serotype O121) infection causing diarrhea and HUS (hemolytic-uremic syndrome)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced E. coli Stx1B antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
E. coli Stx1B
Alternative Names
Pritoxaximab; 1351470-16-0; Shiga toxin 1 B subunit; Shiga toxins
Cellular Localization
Extracellular region or secreted, Plasma membrane
Genecards
11433
Involvement in Disease
Its related pathways are Neuroscience and Monoamine Transport.
Related Pathways
It plays an important role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex, composed of SNAP25, STX1A and SN2, which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are located in the plasma membrane, while Vampire 2 is located in synaptic vesicles. The pairing of the three traps from the n-terminal trap motif to the c-terminal anchor site results in the formation of a trap complex, allowing the membrane to approach and finally fuse. Involved in the calcium-dependent regulation of sperm acrosome exocytosis (PubMed: 23091057). It also plays an important role (similar) in the secretion of insulin or glucagon-like peptide 1 (GLP-1).
Function
Cancer antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
Field of research
Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-190ZP
Host
Chimeric
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
STEC (Shiga-like toxin-producing Escherichia coli or E. coli serotype O121) infection causing diarrhea and HUS (hemolytic-uremic syndrome)

STEC (Shiga-like toxin-producing Escherichia coli or E. coli serotype O121) infection causing diarrhea and HUS (hemolytic-uremic syndrome)

Related Products

Anti-E. coli Stx1B Antibody, Recycling (AES-0622-ZP289) (CAT#: AES-0622-ZP289)
Anti-E. coli Stx1B Antibody, On-Target (AES-0622-ZP945) (CAT#: AES-0622-ZP945)
Anti-E. coli Stx1B Antibody, Half-Life Extended (AES-0622-ZP1273) (CAT#: AES-0622-ZP1273)
Anti-E. coli Stx1B Antibody, Non-Fucosylated (BioBet-190ZP) (CAT#: BioBet-190ZP)
Anti-E. coli Stx1B Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP617) (CAT#: AES-0622-ZP617)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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