Description
ADCC-Enhanced anti-DSG1 (3-30/3h) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Pemphigus foliaceus
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced DSG1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
DSG1
Full Name
desmoglein 1
Background
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
Alternative Names
DSG1; desmoglein 1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; desmoglein-1; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen
Gene ID
1828
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with DSG1 include Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige and Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse.
Related Pathways
Its related pathways are Keratinization and Apoptotic execution phase.
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Field of research
Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn36, Asn110, and Asn180 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
3-30/3h
Description
This is an anti-Dsg1 mAbs useful for studying Dsg1 function and mechanisms of blister formation in PF and for developing targeted therapies and tools to monitor disease activity. Pemphigus foliaceus (PF) is a blistering disease caused by autoantibody to desmoglein 1 (Dsg1) that cause loss of epidermal cell adhesion.
Antibody Indication
Pemphigus foliaceus
