Anti-Discoidin Domain Receptor 2 Antibody, Non-Fucosylated (9M58) (CAT#: BioBet-769ZP) Datasheet

DDR2

discoidin domain receptor tyrosine kinase 2

receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein.

DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2

Plasma membrane

Diseases associated with DDR2 include Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type and Warburg-Cinotti Syndrome.

Its related pathways are Degradation of the extracellular matrix and Activation of cAMP-Dependent PKA.

Tyrosine kinases are involved in the regulation of tissue remodeling (PubMed: 30449416). It is the cell surface receptor of fibrillar collagen and regulates cell differentiation, extracellular matrix remodeling, cell migration and cell proliferation. It is necessary for normal bone development to regulate osteoblast differentiation and chondrocyte maturation through signal pathways involving MAP kinase, leading to the activation of the transcription factor RUNX2. By up-regulating collagenases MMP1, MMP2, MMP13, it regulates extracellular matrix remodeling and promotes cell migration and tumor cell invasion. Promote the migration and proliferation of fibroblasts, thereby promoting skin wound healing.

1.Glycosylated 2.Modification sites at PhosphoSitePlus 3.Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues. Q16832-DDR2_HUMAN Glycosylation at Asn121, Asn213, Asn261, Asn280, and Asn372

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

9M58

Human

Human

This is an antibody that specifically binds to an extracellular domain of human DDR2 and has a therapeutic effect on the solid tumor and cancer.

Cancer; Solid Tumor

Cancer; Solid Tumor