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Anti-Desmocollin 2 Antibody, Non-Fucosylated (545) (CAT#: BioBet-782ZP) Datasheet

Target
Desmocollin 2
Isotype
IgG
Description
ADCC-Enhanced anti-Desmocollin 2 (545) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Desmocollin 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
DSC2
Full Name
desmocollin 2
Background
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.
Alternative Names
DSC2; desmocollin 2; DG2; DSC3; CDHF2; ARVD11; DGII/III; desmocollin-2; cadherin family member 2; desmosomal glycoprotein II/III
Gene ID
1824
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with DSC2 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 11 and Familial Isolated Arrhythmogenic Ventricular Dysplasia, Right Dominant Form.
Related Pathways
Its related pathways are Keratinization and Arrhythmogenic right ventricular cardiomyopathy (ARVC).
Function
Part of the desmosome connection between cells. Participate in the interaction between plaque proteins and intermediate filaments that mediate cell adhesion. The localization (stratification) of epidermal cells may be promoted by mediating the differential adhesion between cells expressing different isoforms.
Post-translational modifications
1.Glycosylation at Asn34, Asn166, Asn392, Asn546, Asn629, and Asn675 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys890
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
545
Host
Human
Species Reactivity
Human
Description
The cytoxicity of anti-desmocollin 2 (DSC2) antibody can be used for treating various cancers including lung, colon, pancreatic, prostate, breast, gastric or liver cancers.
Antibody Indication
Cancer

Cancer

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All products and services are for Research Use Only. Do Not use in humans.

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