Anti-Delta-like 1 homolog Antibody, Non-Fucosylated (LIV-1205) (CAT#: BioBet-772ZP) Datasheet

DLK1

delta-like 1 homolog (Drosophila)

This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

DLK1; delta-like 1 homolog (Drosophila); DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1; protein delta homolog 1; secredeltin; fetal antigen 1; preadipocyte factor 1

Membrane

Diseases associated with DLK1 include Temple Syndrome and Idiopathic Central Precocious Puberty.

Its related pathways are Signaling by GPCR and Notch Signaling Pathway (WikiPathways).

May have a role in neuroendocrine differentiation.

Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

LIV-1205

Humanized

Human

LIV-1205 is a humanized monoclonal antibody targeting cell surface antigen "DLK-1 (Delta-like 1 homolog)" of liver cancer and other solid cancers. DLK-1 is expected to control the proliferation and differentiation of stem cells, progenitor cells, and other immature cells. LIV-1205 have shown potent anti-tumor activity in various cancer models and is expected to have beneficial clinical efficacy.

Cancer

Cancer