Description
Anti-Dectin-1 Antibody, Non-Fucosylated (BioBet-727ZP) is a mouse monoclonal IgG antibody against Dectin-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Immune Disorders
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Dectin-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CLEC7A
Full Name
C-type lectin domain family 7, member A
Background
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1, 3-linked and beta-1, 6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Alternative Names
CLEC7A; C-type lectin domain family 7, member A; BGR; CANDF4; DECTIN1; CLECSF12; C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
Gene ID
64581
UniProt ID
Q8WTT0
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CLEC7A include Candidiasis, Familial, 4 and Aspergillosis.
Related Pathways
Its related pathways are Tuberculosis and CLEC7A (Dectin-1) signaling.
Function
Lectin, as a model receptor for 1,3-strand and -1,6-strand glucan, such as the cell wall components of pathogenic bacteria and fungi. The phosphorylation of SCCMP is induced (by similarity) after binding-dextran. This is necessary for tlr2-mediated inflammation and tlr2-mediated nf-kpa-b activation. Enhance cytokine production in macrophages and dendritic cells. Mediates the production of reactive oxygen species in cells. Mediates the phagocytosis of Candida albicans conidia. It binds to t cells in a way that does not involve t cell surface glycans and plays a role in t cell activation. Stimulates the proliferation of t cells (through similarity).
Post-translational modifications
Phosphorylated on tyrosine residues in response to glucan binding.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
4B2
Description
This is a novel monoclonal antibody against dectin-1 and can be used for the detection, measurement and affinity purification of dectin-1 and other purposes.
Antibody Indication
Immune Disorders
