Anti-CXCR4 Antibody, Highly Galactosylated (BioBet-GA-184ZP) (CAT#: BioBet-GA-184ZP) Datasheet

CXCR4

C-X-C Motif Chemokine Receptor 4

Ulocuplumab; 1375830-34-4; MDX-1338; BMS-936564; CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen;

Plasma membrane, Endosome, Lysosome

Its related pathways are Neuroscience and Signaling by GPCR.

1.The receptor of C-X-C chemokine CXCL12/SDF-1 transmits signals by increasing intracellular calcium levels and enhancing MAPK1/MAPK3 activation. Participate in the AKT signal cascade. Participate in regulating cell migration, such as during wound healing. As a receptor for extracellular ubiquitin; leading to increased intracellular calcium ions and decreased cell cAMP levels. Combined with bacterial lipopolysaccharide (LPS) et mediate lipopolysaccharide-induced inflammation, including monocyte secretion of TNF. Participate in the formation of hematopoiesis and ventricular septum. It may also play an important role in the vascularization of the gastrointestinal tract by regulating the vascular branching and/or remodeling process of endothelial cells. Participate in cerebellar development. In the central nervous system, it can mediate the survival of hippocampal neurons (through similarity).

Cancer antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody

Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. Tyr-7 and Tyr-12 are sulfated in a sequential manner after Tyr-21 is almost fully sulfated, with the binding affinity for CXCL12/SDF-1alpha increasing with the number of sulfotyrosines present. Sulfotyrosines Tyr-7 and Tyr-12 occupy clefts on opposing CXCL12 subunits, thus bridging the CXCL12 dimer interface and promoting CXCL12 dimerization. O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4, κ

BioBet-GA-184ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human CXCR4.

Acute myeloid leukemia (AML)

Acute myeloid leukemia (AML)