Description
Anti-CXCL13 Antibody, Non-Fucosylated (BioBet-757ZP) is a mouse monoclonal IgG antibody against CXCL13. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CXCL13 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CXCL13
Full Name
chemokine (C-X-C motif) ligand 13
Background
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyers patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitts lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Alternative Names
CXCL13; chemokine (C-X-C motif) ligand 13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13; C-X-C motif chemokine 13; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
Gene ID
10563
UniProt ID
Q8WTT0
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with CXCL13 include Angioimmunoblastic T-Cell Lymphoma and Asymptomatic Neurosyphilis.
Related Pathways
Its related pathways are Signaling by GPCR and PEDF Induced Signaling.
Function
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-757ZP
Description
VX5 is a monoclonal antibody that specifically binds human, primate and rodent CXCL13, neutralizes its activity and exhibits therapeutic benefit in mouse models of human autoimmune diseases (e. g. rheumatoid arthritis and multiple sclerosis).
Antibody Indication
Autoimmune Diseases
