Anti-CUB domain containing protein 1 Antibody, Non-Fucosylated (BioBet-692ZP) (CAT#: BioBet-692ZP) Datasheet

CDCP1

CUB domain containing protein 1

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene.

CDCP1; CUB domain containing protein 1; CD318; TRASK; SIMA135; CUB domain-containing protein 1; membrane glycoprotein gp140; transmembrane and associated with src kinases; subtractive immunization M plus HEp3-associated 135 kDa protein

Plasma membrane, Extracellular region or secreted

Diseases associated with CDCP1 include Colorectal Cancer and Lung Cancer.

Its related pathways are Adhesion and NF-kappaB Signaling.

It may be related to cell adhesion and cell matrix binding. It may play a role in the regulation of anchoring and migration or proliferation and differentiation through its phosphorylation. It may be a new marker of leukemia diagnosis and immature hematopoietic stem cell subsets. It belongs to the tetrafilament network and is involved in tumor progression and metastasis.

Cancer antibody; Controls and Markers antibody; Developmental Biology antibody

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-692ZP

Humanized

Human

This is a humanized glycoengineered therapeutic anti-CDCP1 antibody with superior preclinical in vivo efficacy in combination with Paclitaxel. Combining the cytostatic with RG7287 increases tumor growth inhibition compared to RG7287 alone in one xenograft model.

Cancer

Cancer