Anti-CTLA-4 Antibody, Non-Fucosylated (CAT#: BioBet-027ZP) Datasheet

CTLA-4

cytotoxic T-lymphocyte associated protein 4

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Plasma membrane

Diseases associated with CTLA4 include Autoimmune Lymphoproliferative Syndrome, Type V and Celiac Disease 3.

Its related pathways are TCR Signaling (Qiagen) and T cell receptor signaling pathway.

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

1.N-glycosylation is important for dimerization. 2.Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-027ZP

Human

Human

Ipilimumab is a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4). Specifically, it is a fully humanized IgG1 antibody produced in mammalian cell culture. The antibody activates the immune system by inhibiting this major checkpoint.

Advanced Renal Cell Carcinoma
Cutaneous Melanoma
Metastatic Melanoma
Unresectable Melanoma
Metastatic MSI-H/dMMR colorectal cancer

Advanced Renal Cell Carcinoma
Cutaneous Melanoma
Metastatic Melanoma
Unresectable Melanoma
Metastatic MSI-H/dMMR colorectal cancer