Description
Anti-CSF1R Antibody, Highly Galactosylated (BioBet-GA-174ZP) is a humanized IgG4, κ antibody against CSF1R which contains with a high level of galactosylation.
Antibody Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CSF1R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CSF1R
Full Name
Colony Stimulating Factor 1 Receptor
Alternative Names
Colony stimulating factor 1 receptor; CSF-1R; CSF-1-R; macrophage colony-stimulating factor 1 receptor; c-fms; FMS; CD115
Gene ID
1436
UniProt ID
P07333
Cellular Localization
Plasma membrane
Genecards
2433
Involvement in Disease
Its related pathways are Transcriptional misregulation in cancer and Activation of cAMP-Dependent PKA.
Function
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Field of research
Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
BioBet-GA-174ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CSF1R. Cabiralizumab is a human monoclonal antibody that can be potentially used in the treatment of Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS).
Antibody Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
