Description
Anti-CSF1 Antibody, Non-Fucosylated (BioBet-173ZP) is a humanized monoclonal IgG1, κ antibody against CSF1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancers, breast, Pigmented villonodular synovitis (PVNS), Tenosynovitis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CSF1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CSF1
Full Name
Colony Stimulating Factor 1
Alternative Names
Colony stimulating factor 1; "colony stimulating factor 1 macrophage"; M-CSF; macrophage colony stimulating factor 1; MCSF; MGC31930
Gene ID
1435
UniProt ID
P09603
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CSF1 include Pigmented Villonodular Synovitis and Tenosynovial Giant Cell Tumor.
Related Pathways
Its related pathways are Ras signaling pathway and PEDF Induced Signaling.
Function
Hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, are cytokines that play an important role in survival, proliferation and differentiation. Promote the release of pro-inflammatory chemokines, thus playing an important role in innate immunity and inflammation. It plays an important role in regulating the proliferation and differentiation of osteoclasts and regulating bone resorption, and is necessary for normal bone development. Necessary for normal fertility in men and women. Promote the reorganization of the actin cytoskeleton, regulate the formation of membrane folds, cell adhesion and cell migration. Play a role in lipoprotein clearance.
Field of research
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Post-translational modifications
Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-173ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CSF1. Lacnotuzumab is a human monoclonal antibody that can be potentially used in the treatment of Cancers, breast, Pigmented villonodular synovitis (PVNS), Tenosynovitis.
Antibody Indication
Cancers, breast, Pigmented villonodular synovitis (PVNS), Tenosynovitis
Cancers, breast, Pigmented villonodular synovitis (PVNS), Tenosynovitis
