Description
Anti-CSAp Antibody, Non-Fucosylated (BioBet-741ZP) is a humanized monoclonal IgG1k antibody against CSAp. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CSAp antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CSAp
Full Name
Colon-specific antigen-p mucin
Background
Colon-specific antigen-p (CSAp) is a large molecular-sized protein restricted to normal and neoplastic gastrointestinal tissues and to some mucinous ovarian tumors.
Alternative Names
CSAp; Colon-specific antigen-p mucin
UniProt ID
Q8WTT0
Cellular Localization
Cytoskeleton
Involvement in Disease
Diseases associated with CCSAP include Nerve Compression Syndrome and Median Rhomboid Glossitis.
Function
It plays a role in the stability of microtubules (MT), which involves the maintenance of spindle NUMA1. Co-localize with polyglutaminated MTs to promote MT stability and regulate the formation of mitosis of the bipolar spindle. During mitosis, CCSAP binds to the centrosome and the spindle around the centrosome, inhibiting MT depolymerization, and stabilizing the mitotic spindle may play a role in embryonic development. Proper ciliary beating (through similarity) may be required.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1k
Antibody Clone
mu-9
Description
The binding compounds that specifically bind to human TSLPR, can be used in the treatment of inflammatory disorders.
Antibody Indication
Cancer
