Description
Anti-CRCP Antibody, Non-Fucosylated (BioBet-172ZP) is a human monoclonal IgG2, λ antibody against CRCP. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Migraine
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CRCP antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CRCP
Full Name
CGRP Receptor Component
Background
CRCP (CGRP Receptor Component) is a Protein Coding gene.
Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation.
Gene Ontology (GO) annotations related to this gene include nucleotide binding and RNA polymerase III activity.
Alternative Names
CGRP Receptor Component; Calcitonin Gene-Related Peptide-Receptor Component Protein 2; CGRP-Receptor Component Protein; RNA Polymerase III Subunit C9; CGRP-RCP; CGRPRCP; HsC17; RCP9;
Gene ID
27297
UniProt ID
O75575
Cellular Localization
Plasma membrane, Nucleus
Involvement in Disease
Diseases associated with CRCP include Communicating Hydrocephalus.
Related Pathways
Its related pathways are Myometrial Relaxation and Contraction Pathways and Innate Immune System.
Function
1.DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using tetraribonucleoside triphosphate as a substrate. The specific peripheral components of RNA polymerase III synthesize small RNAs, such as 5S rRNA and tRNAs. It plays a key role in sensing and limiting bacterial and DNA virus infection in cells. Participate in the innate immune response as a nuclear and cytoplasmic DNA sensor. It can sense non-self dsDNA as a template for transcription into dsRNA. The non-self RNA polymerase III transcript induces type I interferon and NF-kpa-b through the RIG-I pathway (through similarity). 2.An accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It regulates CGRP responsiveness in various tissues.
Post-translational modifications
1.Modification sites at PhosphoSitePlus 2.Modification sites at neXtProt
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2, λ
Antibody Clone
BioBet-172ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CRCP. Erenumab is a human monoclonal antibody that can be potentially used in the treatment of Migraine.
Antibody Indication
Migraine
