Anti-CRCP Antibody, Non-Fucosylated (BioBet-172ZP) (CAT#: BioBet-172ZP) Datasheet

CRCP

CGRP Receptor Component

CRCP (CGRP Receptor Component) is a Protein Coding gene.

Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation.
Gene Ontology (GO) annotations related to this gene include nucleotide binding and RNA polymerase III activity.

CGRP Receptor Component; Calcitonin Gene-Related Peptide-Receptor Component Protein 2; CGRP-Receptor Component Protein; RNA Polymerase III Subunit C9; CGRP-RCP; CGRPRCP; HsC17; RCP9;

Plasma membrane, Nucleus

Diseases associated with CRCP include Communicating Hydrocephalus.

Its related pathways are Myometrial Relaxation and Contraction Pathways and Innate Immune System.

1.DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using tetraribonucleoside triphosphate as a substrate. The specific peripheral components of RNA polymerase III synthesize small RNAs, such as 5S rRNA and tRNAs. It plays a key role in sensing and limiting bacterial and DNA virus infection in cells. Participate in the innate immune response as a nuclear and cytoplasmic DNA sensor. It can sense non-self dsDNA as a template for transcription into dsRNA. The non-self RNA polymerase III transcript induces type I interferon and NF-kpa-b through the RIG-I pathway (through similarity). 2.An accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It regulates CGRP responsiveness in various tissues.

1.Modification sites at PhosphoSitePlus 2.Modification sites at neXtProt

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2, λ

BioBet-172ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CRCP. Erenumab is a human monoclonal antibody that can be potentially used in the treatment of Migraine.

Migraine

Migraine