Anti-Complement component 5 Antibody, Non-Fucosylated (BioBet-616ZP) (CAT#: BioBet-616ZP) Datasheet

C5

complement component 5

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

C5; complement component 5; C5D; C5a; C5b; ECLZB; CPAMD4; complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein

Extracellular region or secreted

Diseases associated with C5 include Complement Component 5 Deficiency and Eculizumab, Poor Response To.

Its related pathways are Immune response Lectin induced complement pathway and Signaling by GPCR.

C5 activated by C5 convertase initiates the spontaneous assembly of late complement components C5-c9 to form a membrane attack complex. C5b has a short-term binding site for C6. The C5b-C6 complex is the basis for the assembly of the cleavage complex. C5 anaphylactic shock toxin is derived from the proteolytic degradation of complement C5 and is the mediator of the local inflammatory process. Binding to the receptor C5AR1 can cause a variety of reactions, including intracellular calcium release, smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophils. C5a is also a powerful chemokine, which stimulates the movement of polymorphonuclear leukocytes and guides them to migrate to the site of inflammation.

Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042). Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

IFX-1

Humanized

Human

IFX-1 is a first-in-class new monoclonal antibody which was designed to control a key mechanism driving inflammation.

Sepsis

Sepsis