Description
Anti-Collagen Antibody, Non-Fucosylated (BioBet-733ZP) is a humanized monoclonal IgG2 antibody against Collagen. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Solid Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Collagen antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Collagen
Full Name
Collagen
Background
Collagen is the main structural protein in the extracellular space in the various connective tissues in animals. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content.
Alternative Names
Collagen; MT293, TRA093, TRC093
UniProt ID
Q8WTT0
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with COL4A4 include Hematuria, Benign Familial and Alport Syndrome 2, Autosomal Recessive.
Related Pathways
Its related pathways are Integrin Pathway and Collagen chain trimerization.
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Post-translational modifications
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2
Antibody Clone
MT293
Description
MT293 also known as TRC093, is being developed in a phase 1 clinical trial for the treatment of patients with cancer.
Antibody Indication
Solid Tumors
