Anti-Coagulation Factor XI Antibody, Non-Fucosylated (BioBet-848ZP) (CAT#: BioBet-848ZP) Datasheet

F11

coagulation factor XI

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

F11; coagulation factor XI; FXI; PTA; plasma thromboplastin antecedent

Extracellular region or secreted

Diseases associated with F11 include Factor Xi Deficiency and Hemorrhagic Disease.

Its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+.

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Gene Regulation antibody

Autophosphorylated on Ser-2056, Thr-2609, Thr-2638 and Thr-2647. Ser-2056 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C. Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair. S-nitrosylated by GAPDH. Polyubiquitinated by RNF144A, leading to proteasomal degradation.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-848ZP

Human

Human

The antibody capable of binding to the coagulation Factor XI can be used as agents inhibiting platelet aggregation and by this inhibits thrombus formation

Thromboembolism

Thromboembolism