Description
Anti-Clever-1 Antibody, Non-Fucosylated (BioBet-1313ZP) is a humanized monoclonal IgG antibody against Clever-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Clever-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.
Alternative Names
STAB1; stabilin 1; FEX1; FEEL-1; FELE-1; STAB-1; CLEVER-1; stabilin-1; MS-1 antigen; common lymphatic endothelial and vascular endothelial receptor-1; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1; fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with STAB1 include Histiocytosis and Rosai-Dorfman Disease.
Related Pathways
Its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport.
Function
Acts as a scavenger receptor for acetylated low-density lipoproteins. Combined with Gram-positive and Gram-negative bacteria, it may play a role in the defense against bacterial infections. In the endothelial tube formation test, when inhibited, the interaction between cells was significantly reduced, suggesting that it plays a role in angiogenesis. Participate in the delivery of newly synthesized CHID1/SI-CLP from the biosynthesis chamber to the endosome/lysosome system.
Field of research
Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn133, Asn286, Asn312, Asn413, Asn606, Asn673, Asn712, Asn745, Asn816, Asn1087, Asn1096, Asn1170, Asn1178, Asn1222, Asn1274, Asn1378, Asn1471, Asn1626, Asn1727, Asn2107, Asn2222, Asn2261, Asn2290, Asn2334, Asn2347, Asn2379, Asn2393, Asn2400, and Asn2424 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1313ZP
Description
FP-1302 is a fully humanized antibody used to prevent inflammation and cancer spread.
Antibody Indication
Cancer
