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Anti-Claudin-6 Antibody, Non-Fucosylated (BioBet-719ZP) (CAT#: BioBet-719ZP) Datasheet

Target
Claudin-6
Isotype
IgG
Description
Anti-Claudin-6 Antibody, Non-Fucosylated (BioBet-719ZP) is a chimeric monoclonal IgG antibody against Claudin-6. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Ovarian Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Claudin-6 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CLDN6
Full Name
claudin 6
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Alternative Names
CLDN6; claudin 6; claudin-6; skullin; IMAB 027, IMAB027
Gene ID
9074
UniProt ID
P19022
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CLDN6 include Hepatitis C and Hepatitis.
Related Pathways
Its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection.
Function
Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-719ZP
Host
Chimeric
Species Reactivity
Human
Description
IMAB027 is a first-in-class monoclonal antibody selectively binding to the cell surface protein Claudin-6 (CLDN6) which is present in a wide range of cancers, including testicular, ovarian, uterine, and lung cancers. A key advantage of IMAB027 is that CLDN6 is an embryonic antigen which is absent from healthy adult tissue. This unmatched tumor cell specificity of CLDN6 makes IMAB027 a cancer cell selective drug allowing it to efficiently kill tumor cells without harming healthy non-cancerous cells.
Antibody Indication
Ovarian Cancer

Ovarian Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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