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Anti-Claudin-4 Antibody, Non-Fucosylated (KM3907) (CAT#: BioBet-718ZP) Datasheet

Target
Claudin-4
Isotype
IgG
Description
ADCC-Enhanced anti-Claudin-4 (KM3907) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Williams-Beuren syndrome
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Claudin-4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CLDN4
Full Name
claudin 4
Background
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Alternative Names
CLDN4; claudin 4; CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein
Gene ID
1364
UniProt ID
P19022
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CLDN4 include Williams-Beuren Syndrome and Ovarian Cystadenoma.
Related Pathways
Its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection.
Function
The tight junction protein formed by the channel mediates the transport of chloride ions around the cell in the kidney. It plays an important role in the paracellular reabsorption of filtered chloride ions in the renal collection tube. Through calcium-independent cell adhesion activity, Claudins play a major role in tight junction-specific intercellular occlusion.
Post-translational modifications
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
KM3907
Host
Humanized
Species Reactivity
Human
Description
This is a monoclonal antibody useful for a therapeutic agent and diagnosis of a disease associated with a polypeptide encoded by Claudin-4 (hereinafter represented by CLDN4) gene.
Antibody Indication
Williams-Beuren syndrome

Williams-Beuren syndrome

Related Products

Anti-Claudin-4 Antibody, Non-Fucosylated (KM3900) (CAT#: BioBet-717ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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