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Anti-Chordin-like-1 Antibody, Non-Fucosylated (2G2.2) (CAT#: BioBet-711ZP) Datasheet

Target
Chordin-like-1
Isotype
IgG
Description
Anti-Chordin-like-1 Antibody, Non-Fucosylated (BioBet-711ZP) is a humanized monoclonal IgG antibody against Chordin-like-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Diabetes Type 2
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Chordin-like-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CHRDL1
Full Name
chordin-like 1
Background
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
Alternative Names
CHRDL1; chordin-like 1; CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1; chordin-like protein 1; neuralin 1; neuralin-1; ventroptin; neurogenesin-1
Gene ID
91851
UniProt ID
P19022
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with CHRDL1 include Megalocornea and Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome.
Related Pathways
Its related pathways are Signaling by GPCR and Signaling by BMP.
Function
It antagonizes its function by binding to BMP4 and preventing its interaction with the receptor. Changes the fate commitment of neural stem cells from glial formation to nerve formation. By preventing the adoption of glial fate, it helps the neural differentiation of neural stem cells in the brain. It may play a key role in the formation of the dorsoventral axis. May play a role in embryonic bone formation (due to similarity). It may also play an important role in regulating retinal angiogenesis by regulating the role of BMP4 in endothelial cells. It plays an important role in the development of the anterior segment of the eye.
Field of research
It antagonizes its function by binding to BMP4 and preventing its interaction with the receptor. Changes the fate commitment of neural stem cells from glial formation to nerve formation. By preventing the adoption of glial fate, it helps the neural differentiation of neural stem cells in the brain. It may play a key role in the formation of the dorsoventral axis. May play a role in embryonic bone formation (due to similarity). It may also play an important role in regulating retinal angiogenesis by regulating the role of BMP4 in endothelial cells. It plays an important role in the development of the anterior segment of the eye.
Post-translational modifications
1.Glycosylation at Asn118 and Asn291 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
2G2.2
Host
Humanized
Species Reactivity
Human
Description
The antibody binding to CHRDL-1 are used to treat a variety of adipose, glucose, cardiac, and related diseases and disorders.
Antibody Indication
Diabetes Type 2

Diabetes Type 2

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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