Anti-Chemokine receptor CXCR2 Antibody, Non-Fucosylated (BioBet-759ZP) (CAT#: BioBet-759ZP) Datasheet

CXCR2

chemokine (C-X-C motif) receptor 2

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

Plasma membrane

Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Neutrophil Migration.

Its related pathways are Signaling by GPCR and GPCRs, Other.

The receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. The binding of IL-8 to the receptor results in the activation of neutrophils. This reaction is mediated by g protein, which activates the phosphatidylinositol-calcium second messenger system. It binds to IL-8 with high affinity. It also binds to CXCL3, GRO/MGSA and nap2 with high affinity.

Phosphorylated upon ligand binding; which is required for desensitization.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-759ZP

Humanized

Human

The anti-CXC chemokine receptor 2 (CXCR2; IL8RB) antibody in combination with other cancer immunotherapies can prevent migration of myeloid-derived suppressor cells and increased the efficacy of programmed cell death 1-targeting mAbs in a mouse model of rhabdomyosarcoma.

Cancer

Cancer