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Anti-CFR-1 Antibody, Non-Fucosylated (PAT-PA1) (CAT#: BioBet-926ZP) Datasheet

Target
CFR-1
Isotype
IgG
Description
Anti-CFR-1 Antibody, Non-Fucosylated (BioBet-926ZP) is a human monoclonal IgG antibody against CFR-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CFR-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GLG1
Full Name
gastrokine 1
Alternative Names
GLG1; golgi glycoprotein 1; CFR-1; ESL-1; MG160; MG-160; Golgi apparatus protein 1; E-selectin ligand 1; golgi sialoglycoprotein MG-160; cysteine-rich fibroblast growth factor receptor
Gene ID
2734
UniProt ID
Q9UK05
Cellular Localization
Golgi apparatus, Cytoskeleton
Involvement in Disease
Diseases associated with GLG1 include Ecthyma and Trichinosis.
Related Pathways
Its related pathways are Cell surface interactions at the vascular wall and Apoptotic Pathways in Synovial Fibroblasts.
Function
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Post-translational modifications
1.Fucosylation is essential for binding to E-selectin 2.Modification sites at PhosphoSitePlus 3.N-glycosylated. Contains sialic acid residues 4.Glycosylation at Asn165, Asn210, Asn581, Asn677, Thr739, and Asn786
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
PAT-PA1
Host
Human
Species Reactivity
Human
Description
The human antibody PAT-PA1 has already been shown to effectively kill a number of different types of cancer, including significantly reducing gastric and pancreatic tumours in animal models of human cancer, with no adverse side effects.
Antibody Indication
Cancer

Cancer

Related Products

Anti-CFR-1 Antibody, Non-Fucosylated (PAM-1) (CAT#: BioBet-927ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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