Description
Anti-CFD Antibody, Non-Fucosylated (BioBet-170ZP) is a humanized monoclonal Fab - G1 - kappa antibody against CFD. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Age-related macular degeneration (AMD), neovascular (wet)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CFD antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CFD
Full Name
Complement Factor D
Background
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Alternative Names
lampalizumab;1278466-20-8;Anti-Factor D;RG7417;166-32;FCFD4514S;CFD;complement factor D (adipsin);D component of complement (adipsin) , DF, PFD, properdin factor D;complement factor D;ADN;properdin factor D;C3 convertase activator;complement factor D prep
Gene ID
1675
UniProt ID
P00746
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with CFD include Complement Factor D Deficiency and Anorexia Nervosa.
Related Pathways
Its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System.
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Post-translational modifications
Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Fab - G1 - kappa
Antibody Clone
BioBet-170ZP
Description
Recombinant humanized (from mouse) antibody Fab fragment expressed in CHO binding to human CFD. Lampalizumab is a humanized monoclonal antibody designed for the treatment of geographic atrophy secondary to age-related macular degeneration.
Antibody Indication
Age-related macular degeneration (AMD), neovascular (wet)
Age-related macular degeneration (AMD), neovascular (wet)
