Description
Anti-Cell adhesion molecule 2 Antibody, Non-Fucosylated (BioBet-622ZP) is a human monoclonal IgG antibody against Cell adhesion molecule 2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cell adhesion molecule 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CADM2
Full Name
cell adhesion molecule 2
Background
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CADM2; cell adhesion molecule 2; NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2; nectin-like 3; nectin-like protein 3; synaptic cell adhesion molecule 2; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4D
Gene ID
253559
Cellular Localization
Plasma membrane
Related Pathways
Its related pathways are Cell junction organization.
Function
Adhesion molecules interact with other similar members of the nectino family, causing cell aggregation. It is important for synaptic organization and provides regulated transsynaptic adhesion. It preferentially binds to oligodendrocytes.
Post-translational modifications
1.Glycosylation at Asn31, Asn51, and Asn291 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-622ZP
Description
This is a monoclonal antibody (mAb) specific to an epitope on the extracellular domain of CADM2 using conventional hybridoma technology, could be suitable for specific detection of CADM2 expression in tumor cells or tissues.
Antibody Indication
Cancer
