Description
Anti-CD80 Antibody, Highly Galactosylated (BioBet-GA-165ZP) is a chimeric IgG1, λ antibody against CD80 which contains with a high level of galactosylation.
Antibody Indication
Non-Hodgkin's lymphoma (NHL)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD80 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD80
Full Name
CD80 Molecule
Background
CD80 (CD80 Molecule) is a Protein Coding gene.
Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia.
Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system.
Gene Ontology (GO) annotations related to this gene include coreceptor activity.
An important paralog of this gene is CD86.
Alternative Names
Galiximab; 357613-77-5; IDEC-114; 16C10; CD80; CD80 molecule; CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7 1 antigen), CD80 molecule; T-lymphocyte activation antigen CD80; B lymphocyte activation antigen B7; B7 1; B7.1; activation B7-1 antigen;
Gene ID
941
UniProt ID
P33681
Cellular Localization
Membrane
Genecards
1700
Involvement in Disease
Its related pathways are Nur77 Signaling in T-Cell and RET signaling.
Related Pathways
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
Field of research
1.Glycosylation at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, and Asn232 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, λ
Antibody Clone
BioBet-GA-165ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD8. Galiximab is a monoclonal antibody designed for the treatment of B-cell lymphoma. As of September 2009, The drug is a chimeric antibody from Macaca irus and Homo sapiens.
Antibody Indication
Non-Hodgkin's lymphoma (NHL)
Non-Hodgkin's lymphoma (NHL)
