Description
ADCC-Enhanced anti-CD70 (ARGX-110) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases; Cancer; Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD70 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD70
Full Name
CD70 molecule
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Alternative Names
CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7
Gene ID
970
UniProt ID
Q5ZPR3
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Acute Myocarditis.
Related Pathways
Its related pathways are PEDF Induced Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Function
Cytokines are ligands for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, especially in the antiviral response. After CD27 is bound, it induces co-stimulation of T cell proliferation and enhances the production of cytolytic T cells.
Post-translational modifications
1.Glycosylation at Asn63, Tyr74, and Asn170 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ARGX-110
Description
ARGX-110 is a CD70-specific antibody that potently modulates both known functions of CD70: tumor cell proliferation and survival, and tumor immune escape.
Antibody Indication
Autoimmune Diseases; Cancer; Inflammatory Diseases
Autoimmune Diseases; Cancer; Inflammatory Diseases
