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Anti-CD48 Antibody, Non-Fucosylated (BioBet-674ZP) (CAT#: BioBet-674ZP) Datasheet

Target
CD48
Isotype
IgG2a
Description
Anti-CD48 Antibody, Non-Fucosylated (BioBet-674ZP) is a chimeric monoclonal IgG2a antibody against CD48. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD48 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD48
Full Name
CD48 molecule
Background
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CD48; CD48 molecule; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102; CD48 antigen; TCT.1; BCM1 surface antigen; SLAM family member 2; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); signaling lymphocytic activation molecule 2
Gene ID
962
UniProt ID
Q5ZPR3
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CD48 include Lymphoproliferative Syndrome, X-Linked, 1 and Cone-Rod Dystrophy 6.
Related Pathways
Its related pathways are Gastric Cancer Network 2 and Cell surface interactions at the vascular wall.
Function
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
Field of research
Immune System antibody
Post-translational modifications
1.Glycosylation at Asn40, Asn44, Asn104, Asn162, Asn189, and Asn206 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2a
Antibody Clone
BioBet-674ZP
Host
Chimeric
Species Reactivity
Human
Description
This is an antibody directed against the CD48 antigen has a strong anti-tumour effect in an animal model. The anti-tumour effect has been demonstrated in an animal model where treatment of mice containing tumour cells with an anti-CD48 antibody gave long term survival (cures) over those treated with a control antibody.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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