Description
Anti-CD40 Antibody, Non-Fucosylated (BioBet-146ZP) is a humanized monoclonal IgG1 antibody against CD40. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Lymphoma, B cell
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD40 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD40
Full Name
CD40 Molecule
Background
CD40 (CD40 Molecule) is a Protein Coding gene.
Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Cd40 Ligand Deficiency.
Among its related pathways are NLR Proteins and Cytokine Signaling in Immune system.
Gene Ontology (GO) annotations related to this gene include enzyme binding and receptor activity.
An important paralog of this gene is TNFRSF11A.
Alternative Names
Tumor necrosis factor receptor superfamily member 5; TNFRSF5; p50
Gene ID
958
UniProt ID
P25942
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Immunodeficiency With Hyper-Igm, Type 1.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and NF-KappaB Family Pathway.
Function
TNFSF5/CD40LG receptor (PubMed: 31331973). ERK is activated by TRAF6- and map3k8-mediated signals in macrophages and B cells, leading to the induction of immunoglobulin secretion (by similarity).
Field of research
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Pro-B Cell Marker antibody; Pre-B Cell Marker antibody
Post-translational modifications
1.Glycosylation at Asn153 and Asn180 2.Glycosylation at Asn153 and Asn180 3.Glycosylation at Asn153 and Asn180
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-146ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. Dacetuzumab (also known as SGN-40 or huS2C6) is a humanized monoclonal antibody being developed for the treatment of CD40-positive cancers like non-Hodgkin's lymphoma and hematological malignancies.
Antibody Indication
Lymphoma, B cell
