Book a Meeting

Anti-CD4 Fc Silent Antibody (FCS-141P) (CAT#: FCS-141P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human IgG1, κ
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
CD4
Official Name
CD4
Full Name
CD4 Molecule
Background
CD4 (CD4 Molecule) is a Protein Coding gene.
Diseases associated with CD4 include Okt4 Epitope Deficiency and Pilonidal Sinus.
Among its related pathways are G-protein signaling N-RAS regulation pathway and PEDF Induced Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.
Alternative Names
CD4; CD4 molecule; CD4 antigen (p55); T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut
Gene ID
920
Uniprot ID
P01730

Related Products

Anti-CD4 Fc Silent Antibody (DB81) (CAT#: BioBet-F411P)
Anti-CD4 Fc Silent Antibody (CAT 13.9B4) (CAT#: BioBet-F415P)
Anti-CD4 Fc Silent Antibody (CE9.1 (Clenoliximab)) (CAT#: BioBet-F413P)
Anti-CD4 Fc Silent Antibody (YTS 191.1) (CAT#: BioBet-F412P)
Anti-CD4 Fc Silent Antibody (FCS-139P) (CAT#: FCS-139P)
Anti-CD4 Fc Silent Antibody (898H2-6-15) (CAT#: BioBet-F416P)
Anti-CD4 Fc Silent Antibody (FCS-140P) (CAT#: FCS-140P)
Anti-CD4 Fc Silent Antibody (YTS 191.1) (CAT#: BioBet-F414P)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.