Anti-CD3E Antibody, Non-Fucosylated (BioBet-135ZP) (CAT#: BioBet-135ZP) Datasheet

CD3E

CD3e Molecule

CD3E (CD3e Molecule) is a Protein Coding gene.
Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
Among its related pathways are G-protein signaling N-RAS regulation pathway and Toll-like receptor signaling pathway.
Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and signal transducer activity.

Otelixizumab; 881191-44-2; TRX4; ChAglyCD3; GSK2136525; TRX4; CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain;

Plasma membrane

Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.

Its related pathways are Nur77 Signaling in T-Cell and NF-KappaB Family Pathway.

Part of the TCR-CD3 complex exists on the surface of t lymphocytes and plays an important role in the adaptive immune response. When antigen-presenting cells (APCs) activate T cell receptors (TCR), TCR-mediated signals are transmitted through the cell membrane through the CD3 chain CD3D, CD3E, CD3G, and CD3Z. The cytoplasmic domains of all CD3 chains contain tyrosine-based immune receptor activation motifs (ITAMs). When TCR is involved, these motifs are phosphorylated by Src family protein tyrosine kinases LCK and FYN, leading to the activation of downstream signaling pathways (PubMed: 2470098). In addition to the role of signal transduction in the activation of T cells, CD3E also plays an important role in the correct development of T cells. By forming two heterodimers, CD3D/CD3E and CD3G/CD3E, the assembly of the TCR-CD3 complex is initiated. The endocytic sequence that exists through the cytoplasmic region of CD3E participates in the internalization of the TCR-CD3 complex and the down-regulation of the cell surface (PubMed: 10384095, PubMed: 26507128).

Cancer antibody; Developmental Biology antibody; Immune System antibody; Lymphocyte Marker antibody; Inflammatory Cell Marker antibody; T-cell Marker antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody

1.Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 2.Ubiquitination at Lys104 and Lys177 3.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, λ

BioBet-135ZP

Humanized

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from rat) antibody to Human CD3E. Otelixizumab, also known as TRX4, is a monoclonal antibody, which is being developed for the treatment of type 1 diabetes and other autoimmune diseases.

Psoriasis

Psoriasis