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Anti-CD30L Antibody, Non-Fucosylated (MOG35-55) (CAT#: BioBet-1400ZP) Datasheet

Target
CD30L
Isotype
IgG
Description
Anti-CD30L Antibody, Non-Fucosylated (BioBet-1400ZP) is a humanized monoclonal IgG antibody against CD30L. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD30L antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFSF8
Full Name
tumor necrosis factor (ligand) superfamily, member 8
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkins and some non-Hodgkins lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
TNFSF8; tumor necrosis factor (ligand) superfamily, member 8; CD153; CD30L; CD30LG; tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand
Gene ID
944
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFSF8 include Anaplastic Large Cell Lymphoma and Lymphoma, Hodgkin, Classic.
Related Pathways
Its related pathways are PEDF Induced Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Function
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
Post-translational modifications
1.Glycosylation at Asn81, Asn109, Asn153, Asn189, and Asn201 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
MOG35-55
Host
Humanized
Species Reactivity
Human
Description
The antibody against CD30L can be used for treating autoimmune and chronic inflammatory conditions.
Antibody Indication
Inflammatory Disease

Inflammatory Disease

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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