Description
The Highly Galactosylated Anti-CD30 (Brentuximab vedotin), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Hodgkin's disease (HD)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD30 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF8
Full Name
TNFRSF8 Gene(Protein Coding)
TNF Receptor Superfamily Member 8
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Alternative Names
Iratumumab;640735-09-7;MDX-060;5F11;TNFRSF8;tumor necrosis factor receptor superfamily, member 8;CD30, D1S166E;tumor necrosis factor receptor superfamily member 8;KI 1;Ki-1 antigen;CD30L receptor;cytokine receptor CD30;lymphocyte activation antigen CD30;C
Gene ID
943
UniProt ID
P28908
Cellular Localization
Plasma membrane
Genecards
11923
Involvement in Disease
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Related Pathways
Receptor for TNFSF8/CD30L (PubMed:8391932). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Function
Cancer antibody; Immune System antibody
Field of research
Phosphorylated on serine and tyrosine residues.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Brentuximab vedotin
Description
The Highly Galactosylated Anti-CD30 (Brentuximab vedotin), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Hodgkin's disease (HD)
