Description
Anti-CD3 epsilon Antibody, Highly Galactosylated (BioBet-GA-133ZP) is a human IgG1, κ antibody against CD3 epsilon which contains with a high level of galactosylation.
Antibody Indication
Atherosclerosis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD3 epsilon antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD3E
Full Name
CD3e Molecule
Background
CD3E (CD3e Molecule) is a Protein Coding gene.
Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta.
Among its related pathways are G-protein signaling N-RAS regulation pathway and Toll-like receptor signaling pathway.
Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and signal transducer activity.
Alternative Names
Foralumab;946415-64-1;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell antigen receptor complex, e
Gene ID
916
UniProt ID
P07766
Cellular Localization
Plasma membrane
Genecards
1674
Involvement in Disease
Its related pathways are Nur77 Signaling in T-Cell and NF-KappaB Family Pathway.
Related Pathways
Part of the TCR-CD3 complex exists on the surface of t lymphocytes and plays an important role in the adaptive immune response. When antigen-presenting cells (APCs) activate T cell receptors (TCR), TCR-mediated signals are transmitted through the cell membrane through the CD3 chain CD3D, CD3E, CD3G, and CD3Z. The cytoplasmic domains of all CD3 chains contain tyrosine-based immune receptor activation motifs (ITAMs). When TCR is involved, these motifs are phosphorylated by Src family protein tyrosine kinases LCK and FYN, leading to the activation of downstream signaling pathways (PubMed: 2470098). In addition to the role of signal transduction in the activation of T cells, CD3E also plays an important role in the correct development of T cells. By forming two heterodimers, CD3D/CD3E and CD3G/CD3E, the assembly of the TCR-CD3 complex is initiated. The endocytic sequence that exists through the cytoplasmic region of CD3E participates in the internalization of the TCR-CD3 complex and the down-regulation of the cell surface (PubMed: 10384095, PubMed: 26507128).
Function
Cancer antibody; Developmental Biology antibody; Immune System antibody; Lymphocyte Marker antibody; Inflammatory Cell Marker antibody; T-cell Marker antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody
Field of research
1.Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8 2.Ubiquitination at Lys104 and Lys177 3.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-133ZP
Description
Recombinant monoclonal antibody to CD3 epsilon. Foralumab is an immunomodulator. It binds to CD3 epsilon.
Antibody Indication
Atherosclerosis
