Description
Anti-CD248 Antibody, Highly Galactosylated (BioBet-GA-116ZP) is a chimeric/humanized hybrid IgG1, κ antibody against CD248 which contains with a high level of galactosylation.
Antibody Indication
Solid tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD248 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD248
Full Name
CD248 Molecule
Background
CD248 (CD248 Molecule) is a Protein Coding gene.
Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding.
An important paralog of this gene is CD93.
Alternative Names
Ontuxizumab; 946415-62-9; MORAb-004; CD248; CD248 molecule, endosialin; CD164 sialomucin like 1, CD164L1, CD248 antigen, endosialin; endosialin; TEM1; tumor endothelial marker 1; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; CD164L1; MGC119478;
Gene ID
57124
UniProt ID
Q9HCU0
Cellular Localization
Membrane
Genecards
18219
Related Pathways
May play a role in tumor angiogenesis.
Function
Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody
Field of research
1.O-glycosylated with sialylated oligosaccharides 2.May be N-glycosylated 3.Glycosylation at Thr60, Thr401, Thr428, Thr448, Thr456, Thr459, Thr472, Thr519, Thr541, Thr543, Thr544, Thr545, Thr587, Thr593, Thr594, Thr595, Ser598, Ser601, Thr612, Thr619, Ser623, Ser625, Thr627, Thr630, Ser631, Thr636, and Ser640 4.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-116ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant chimeric/humanized hybrid (mouse/human) antibody expressed in CHO binding to human CD248. Ontuxizumab is a monoclonal antibody designed for the treatment of cancer.
Antibody Indication
Solid tumors
