Description
Anti-CD200 receptor Antibody, Non-Fucosylated (BioBet-648ZP) is a humanized monoclonal IgG1 antibody against CD200 receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases; Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD200 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD200R1
Full Name
CD200 receptor 1
Background
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.
Alternative Names
CD200R1; CD200 receptor 1; OX2R; MOX2R; CD200R; HCRTR2; cell surface glycoprotein CD200 receptor 1; MOX2 receptor; CD200 cell surface glycoprotein receptor; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200
Gene ID
131450
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CD200R1 include Human Herpesvirus 8 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1.
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
CD200/OX2 cell surface glycoprotein inhibitory receptor. By inhibiting the expression of pro-inflammatory molecules, including tnf--, interferon, and inducible nitric oxide synthase (iNOS) in response to specific stimuli to limit inflammation. It also binds to CD200, the homologue of HHV-8 K14 virus, and has the same affinity and kinetics as the host CD200.
Post-translational modifications
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-648ZP
Description
The antibody binding compounds specific for the human inhibitory CD200R can be used to modulate its activity in inflammatory and autoimmune disorders.
Antibody Indication
Autoimmune Diseases; Inflammatory Diseases
Autoimmune Diseases; Inflammatory Diseases
