Anti-CD18 Antibody, Highly Galactosylated (BioBet-GA-334ZP) (CAT#: BioBet-GA-334ZP) Datasheet

ITGB2

Integrin Subunit Beta 2

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Erlizumab;211323-03-4;rhuMAb CD18;rhuMAb;ITGB2;integrin, beta 2 (complement component 3 receptor 3 and 4 subunit);CD18, integrin, beta 2 (antigen CD18 (p95), lymphocyte function associated antigen 1;macrophage antigen 1 (mac 1) beta subunit) , MFI7;integr

Plasma membrane

Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.

Integrin ITGAL/ITGB2 is the receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted ubiquitin-like protein ISG15; this interaction is mediated by ITGAL. The integrins ITGAM/ITGB2 and ITGAX/ITGB2 are the receptors of the third complement component iC3b fragment and fibrinogen. The integrin ITGAX/ITGB2 recognizes the G-P-R sequence in the alpha chain of fibrinogen. Integrin ITGAM/ITGB2 recognizes the P1 and P2 peptides of the fibrinogen-gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor x. Integrin ITGAD/ITGB2 is the receptor of ICAM3 and VCAM1. Contributes to natural killer cell toxicity. Participate in leukocyte adhesion and leukocyte transport, including T cells and neutrophils. Through PTK2B/pyk2-mediated activation, neutrophil migration is triggered during lung injury. The integrin ITGAL/ITGB2 is related to ICAM3, which contributes to the phagocytosis of macrophages and neutrophils. Related to the subunit ITGAM/CD11b, cd177-prtn3 is required for TNF-mediated neutrophil activation.

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-GA-334ZP

Humanized

Human

Recombinant antibody Fragment F(ab')₂ to CD18. Erlizumab, also known as rhuMAb, is a recombinant humanized monoclonal antibody that was an experimental immunosuppressive drug. Erlizumab treats heart attack, stroke, and traumatic shock.

Unknown

Unknown