Anti-CD148 receptor tyrosine kinase Antibody, Non-Fucosylated (Ab-4) (CAT#: BioBet-1523ZP) Datasheet

PTPRJ

protein tyrosine phosphatase, receptor type, J

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ; protein tyrosine phosphatase, receptor type, J; DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; receptor-type tyrosine-protein phosphatase eta; DEP-1; R-PTP-J; HPTP eta; CD148 antigen; density-enhanced phosphatase 1; protein-tyrosine phosphatase eta; human density enhanced phosphatase-1; protein-tyrosine phosphatase receptor type J; susceptibility to colon cancer 1, mouse, homolog of; protein tyrosine phosphatase, receptor type, J polypeptide;

Plasma membrane

Diseases associated with PTPRJ include Colorectal Cancer and Cogan Syndrome.

Its related pathways are Signaling by GPCR and Development HGF signaling pathway.

Tyrosine phosphatase, can dephosphorylate or contribute to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 Phosphorylation. It plays a role in cell adhesion, migration, proliferation and differentiation. Involved in the development of blood vessels. Regulators of macrophage adhesion and proliferation. It has a positive effect on cell matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulation of cell proliferation. Pdgf-stimulated negative regulator of cell migration; dephosphorylation by PDGFR. Positive regulators of endothelial cell survival, vegf-induced SRC and AKT activation; dephosphorylated by KDR. Negative regulation of EGFR signaling pathway; epidermal growth factor receptor dephosphorylation. Enhance the barrier function of epithelial connections during the reorganization process. Negative regulation of T cell receptor (TCR) signaling. When T-cell TCR is activated, it is up-regulated and rejected outside the immune synapse. When T-cell antigen-presenting cells (APC) are detached, they are no longer rejected, which can dephosphorylate PLCG1 and LAT, and down-regulate signal transduction.

Signaling Transduction antibody

N- and O-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

Ab-4

Human

Human

Anti-CD148 antibody bind CD148 epitopes and activate CD148 function, such as inhibition of angiogenesis. It can be used in a number of diseases known to be associated with deregulated or undesired angiogenesis.

Rheumatoid Arthritis; Inflammatory Disease; Hemangioblastoma

Rheumatoid Arthritis; Inflammatory Disease; Hemangioblastoma