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Anti-CCR7 Antibody, Non-Fucosylated (BioBet-637ZP) (CAT#: BioBet-637ZP) Datasheet

Target
CCR7
Isotype
IgG
Description
Anti-CCR7 Antibody, Non-Fucosylated (BioBet-637ZP) is a humanized monoclonal IgG antibody against CCR7. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CCR7 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CCR7
Full Name
chemokine (C-C motif) receptor 7
Background
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Alternative Names
CCR7; chemokine (C-C motif) receptor 7; BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; C-C chemokine receptor type 7; MIP-3 beta receptor; CC chemokine receptor 7; Bukitts lymphoma receptor 2; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; Epstein-Barr virus-induced G-protein coupled receptor 1
Gene ID
1236
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CCR7 include Chronic Actinic Dermatitis and Lymphadenitis.
Related Pathways
Its related pathways are Signaling by GPCR and Akt Signaling.
Function
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Field of research
Immune System antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn36 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-637ZP
Host
Humanized
Species Reactivity
Human
Description
This is a novel anti-human CCR7 antibody specifically binding to an extracellular domain of human CCR7, useful as a therapeutic agent for tissue fibrosis or cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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